期刊
CHINESE CHEMICAL LETTERS
卷 28, 期 3, 页码 597-601出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2016.10.036
关键词
Atractylodes lancea; Eudesmane-type sesquiterpenoid; Guaiane-type sesquiterpenoid; C14-Polyacetylene; Anti-inflammatory effect
资金
- National Science and Technology Project of China [2012ZX09301002-001003]
Four new glycosides including a eudesmane-type sesquiterpenoid (1), a guaiane-type sesquiterpenoid (2), and two C-14-polyacetylenes (3, 4) were isolated from the rhizomes of Atractylodes lancea. Their structures were elucidated by means of spectroscopic and spectrometric analyses (UV, IR, 1D and 2D NMR, and HR-ESIMS). The absolute configurations of their aglycones were established based on the experimental and calculated electronic circular dichroism (ECD), whereas those of monosaccharide moieties were determined by the GC method after chiral derivatization. Compound 4 showed weak anti-inflammatory effects on the LPS-induced NO production in microglia BV2 cells at a concentration of 10 mu mol L (1). (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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