期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2015, 期 32, 页码 6994-6998出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201501039
关键词
Synthetic methods; Multicomponent reactions; Mechanochemistry; Biginelli reaction; Ball mill
资金
- Department of Science and Technology (DST) (New Delhi, India) [INT/FINLAND/P-06, SR/S1/IC-59/2010]
- University Grants Commission (UGC)
- Council of Scientific and Industrial Research (CSIR) (India)
We report here an understanding of systems chemistry on small molecules through covalent mechanochemistry. As a proof-of-concept, the multicomponent Biginelli reaction by subcomponent synthesis was considered as a model system. Reactions were performed under solvent-free, metal-free, mechanochemical (ball milling) and ambient laboratory conditions. Br+-catalyzed oxidation of benzyl alcohols led to the product benzaldehydes and byproduct H+ which were further promoted as component and catalyst, respectively, for a cascade transformation to dihydropyrimidones within the same reaction pot. Remarkably, in solution, the reaction system could not be reproduced at room temperature even after 24 h.
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