期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 61, 期 3, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01228-16
关键词
drug potency; host cell; Leishmania donovani
资金
- British Society for Antimicrobial Chemotherapy [GA2012_23R]
- UK Medical Research Council under the MRC/DFID [MR/J008702/1]
- UK Department for International Development under the MRC/DFID [MR/J008702/1]
- Wellcome Trust [079838]
This study characterized the in vitro potencies of antileishmanial agents against intracellular Leishmania donovani amastigotes in primary human macrophages, obtained with or without CD14-positive monocyte enrichment, phorbol 12-myristate 13-acetate (PMA)-differentiated THP-1 cells, and mouse peritoneal exudate macrophages (PEMs). Host cell-dependent potency was confirmed for pentavalent and trivalent antimony. Fexinidazole was inactive against intracellular amastigotes across the host cell panel. Fexinidazole sulfone, (R)-PA-824, (S)-PA-824, and VL-2098 displayed similar potency in all of the host cells tested.
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