期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2015, 期 12, 页码 2727-2732出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201500051
关键词
Mechanochemistry; Organocatalysis; Ritter reaction; Amides
资金
- Croatian Ministry of Science, Education and Sports
- Ruder Boskovic Institute
A fast and efficient mechanochemical Ritter reaction between alcohols and nitriles under mild conditions is demonstrated. The reaction proceeds rapidly at room temperature in a solvent-free or low-solvent environment by using a BrOnsted acid catalyst. Its general application has been verified through a substrate screening comprising a wide range of functionalized nitriles as well as secondary and tertiary alcohols.
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