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Martin Steger et al.
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ANNALS OF NEUROLOGY (2015)
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BIOCHEMICAL SOCIETY TRANSACTIONS (2015)
Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction
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BRAIN (2015)
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EMBO JOURNAL (2015)
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Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation
Agne Kazlauskaite et al.
EMBO REPORTS (2015)
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Heterozygote carriers for CNVs in PARK2 are at increased risk of Parkinson's disease
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HUMAN MOLECULAR GENETICS (2015)
VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin
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HUMAN MOLECULAR GENETICS (2015)
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JOURNAL OF CELL BIOLOGY (2015)
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JOURNAL OF NEUROSCIENCE (2015)
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The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
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MOLECULAR CELL (2015)
Mechanism of phospho-ubiquitin-induced PARKIN activation
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NATURE (2015)
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
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NATURE (2015)
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NATURE CELL BIOLOGY (2015)
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NATURE NEUROSCIENCE (2015)
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NEUROBIOLOGY OF DISEASE (2015)
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PARKINSONISM & RELATED DISORDERS (2015)
Parkin loss leads to PARIS-dependent declines in mitochondrial mass and respiration
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Mitochondrial dysfunction and mitophagy in Parkinson's: from familial to sporadic disease
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TRENDS IN BIOCHEMICAL SCIENCES (2015)
Oxidative stress and Parkinson's disease
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FRONTIERS IN NEUROANATOMY (2015)
The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilization
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ONCOTARGET (2015)
PINK1 Kinase Catalytic Activity Is Regulated by Phosphorylation on Serines 228 and 402
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JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
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BIOCHEMICAL JOURNAL (2014)
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EMBO JOURNAL (2014)
Hexokinase activity is required for recruitment of parkin to depolarized mitochondria
Melissa K. McCoy et al.
HUMAN MOLECULAR GENETICS (2014)
The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy
Tom Cornelissen et al.
HUMAN MOLECULAR GENETICS (2014)
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The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagy
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MOLECULAR CELL (2014)
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MOVEMENT DISORDERS (2014)
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Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
Yvette C. Wong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling
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SCIENCE (2014)
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PLOS COMPUTATIONAL BIOLOGY (2014)
PINK1 is degraded through the N-end rule pathway
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AUTOPHAGY (2013)
Genome-wide RNAi screen identifies ATPase inhibitory factor 1 (ATPIF1) as essential for PARK2 recruitment and mitophagy
Valerie Lefebvre et al.
AUTOPHAGY (2013)
The TOMM machinery is a molecular switch in PINK1 and PARK2/PARKIN-dependent mitochondrial clearance
Giulia Bertolin et al.
AUTOPHAGY (2013)
Mitochondrial morphology in mitophagy and macroautophagy
Ligia C. Gomes et al.
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PINK1 protects against cell death induced by mitochondrial depolarization, by phosphorylating Bcl-xL and impairing its pro-apoptotic cleavage
G. Arena et al.
CELL DEATH AND DIFFERENTIATION (2013)
Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression
Peter Reinhardt et al.
CELL STEM CELL (2013)
Structure of the human Parkin ligase domain in an autoinhibited state
Tobias Wauer et al.
EMBO JOURNAL (2013)
TRAP1 rescues PINK1 loss-of-function phenotypes
Li Zhang et al.
HUMAN MOLECULAR GENETICS (2013)
Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation
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HUMAN MOLECULAR GENETICS (2013)
Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation
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JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding
Michael Lazarou et al.
JOURNAL OF CELL BIOLOGY (2013)
Mutations in the Intellectual Disability Gene Ube2a Cause Neuronal Dysfunction and Impair Parkin-Dependent Mitophagy
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MOLECULAR CELL (2013)
Lewy body pathology in a patient with a homozygous Parkin deletion
Saori Miyakawa et al.
MOVEMENT DISORDERS (2013)
Parkin disease and the Lewy body conundrum
Karen M. Doherty et al.
MOVEMENT DISORDERS (2013)
Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization
Shireen A. Sarraf et al.
NATURE (2013)
High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy
Samuel A. Hasson et al.
NATURE (2013)
The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy
Victoria S. Burchell et al.
NATURE NEUROSCIENCE (2013)
Monogenic Parkinson's disease and parkinsonism: Clinical phenotypes and frequencies of known mutations
Andreas Puschmann
PARKINSONISM & RELATED DISORDERS (2013)
Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan
Anil Rana et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo
Evelyn S. Vincow et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Structure of Parkin Reveals Mechanisms for Ubiquitin Ligase Activation
Jean-Francois Trempe et al.
SCIENCE (2013)
PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria
Yun Chen et al.
SCIENCE (2013)
Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease
A. C. Costa et al.
CELL DEATH & DISEASE (2013)
A molecular explanation for the recessive nature of parkin-linked Parkinson's disease
Donald E. Spratt et al.
NATURE COMMUNICATIONS (2013)
Structure and function of Parkin E3 ubiquitin ligase reveals aspects of RING and HECT ligases
B. E. Riley et al.
NATURE COMMUNICATIONS (2013)
A Vesicular Transport Pathway Shuttles Cargo from Mitochondria to Lysosomes
Vincent Soubannier et al.
CURRENT BIOLOGY (2012)
Role of PINK1 Binding to the TOM Complex and Alternate Intracellular Membranes in Recruitment and Activation of the E3 Ligase Parkin
Michael Lazarou et al.
DEVELOPMENTAL CELL (2012)
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment
Andrew W. Greene et al.
EMBO REPORTS (2012)
Expression of Pink1 with α-synuclein in the dopaminergic neurons of Drosophila leads to increases in both lifespan and healthspan
A. M. Todd et al.
GENETICS AND MOLECULAR RESEARCH (2012)
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1
Xinglong Wang et al.
HUMAN MOLECULAR GENETICS (2012)
Analysis of the Regulatory and Catalytic Domains of PTEN-Induced Kinase-1 (PINK1)
Chou Hung Sim et al.
HUMAN MUTATION (2012)
Pink1 Kinase and Its Membrane Potential (Δψ)-dependent Cleavage Product Both Localize to Outer Mitochondrial Membrane by Unique Targeting Mode
Dorothea Becker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Voltage-dependent Anion Channels (VDACs) Recruit Parkin to Defective Mitochondria to Promote Mitochondrial Autophagy
Yu Sun et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein
Jingwen Niu et al.
JOURNAL OF NEUROCHEMISTRY (2012)
Human mitochondrial DNA: roles of inherited and somatic mutations
Eric A. Schon et al.
NATURE REVIEWS GENETICS (2012)
ATP13A2 regulates mitochondrial bioenergetics through macroautophagy
Aaron M. Gusdon et al.
NEUROBIOLOGY OF DISEASE (2012)
NEUROTOXIN-BASED MODELS OF PARKINSON'S DISEASE
J. Bove et al.
NEUROSCIENCE (2012)
The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax
Bethann N. Johnson et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria
Kei Okatsu et al.
NATURE COMMUNICATIONS (2012)
PINK1-mediated phosphorylation of the Parkin ubiquitin-like domain primes mitochondrial translocation of Parkin and regulates mitophagy
Kahori Shiba-Fukushima et al.
SCIENTIFIC REPORTS (2012)
Genetics of Parkinson's Disease
Christine Klein et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
Chandana Kondapalli et al.
OPEN BIOLOGY (2012)
Mitochondrial Function and Dysfunction: An Update
Robert E. Davis et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
Alexander Zimprich et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
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Carles Vilarino-Gueell et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
Regulation of PINK1-Parkin-mediated mitophagy
Wolfdieter Springer et al.
AUTOPHAGY (2011)
PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease
Joo-Ho Shin et al.
CELL (2011)
PINK1 and Parkin Target Miro for Phosphorylation and Degradation to Arrest Mitochondrial Motility
Xinnan Wang et al.
CELL (2011)
LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress
Ha Nam Nguyen et al.
CELL STEM CELL (2011)
Autoregulation of Parkin activity through its ubiquitin-like domain
Viduth K. Chaugule et al.
EMBO JOURNAL (2011)
PINK1 cleavage at position A103 by the mitochondrial protease PARL
Emma Deas et al.
HUMAN MOLECULAR GENETICS (2011)
DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy
Kelly Jean Thomas et al.
HUMAN MOLECULAR GENETICS (2011)
Broad activation of the ubiquitin-proteasome system by Parkin is critical for mitophagy
Nickie C. Chan et al.
HUMAN MOLECULAR GENETICS (2011)
Phylogenetic and In Silico Structural Analysis of the Parkinson Disease-Related Kinase PINK1
Fernando Cardona et al.
HUMAN MUTATION (2011)
Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
Ken Nakamura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Depletion of PINK1 affects mitochondrial metabolism, calcium homeostasis and energy maintenance
Bavo Heeman et al.
JOURNAL OF CELL SCIENCE (2011)
Phenotype analysis in patients with early onset Parkinson's disease with and without parkin mutations
Hee Jin Kim et al.
JOURNAL OF NEUROLOGY (2011)
Parkin Interacts with Ambra1 to Induce Mitophagy
Cindy Van Humbeeck et al.
JOURNAL OF NEUROSCIENCE (2011)
The AAA-ATPase p97 is essential for outer mitochondrial membrane protein turnover
Shan Xu et al.
MOLECULAR BIOLOGY OF THE CELL (2011)
UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids
Dawn M. Wenzel et al.
NATURE (2011)
WHAT GENETICS TELLS US ABOUT THE CAUSES AND MECHANISMS OF PARKINSON'S DISEASE
Olga Corti et al.
PHYSIOLOGICAL REVIEWS (2011)
Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo
Fredrik H. Sterky et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both
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AUTOPHAGY (2010)
The PINK1/Parkin-mediated mitophagy is compromised by PD-associated mutations
Sven Geisler et al.
AUTOPHAGY (2010)
PINK1-linked parkinsonism is associated with Lewy body pathology
Lluis Samaranch et al.
BRAIN (2010)
Calcium, cellular aging, and selective neuronal vulnerability in Parkinson's disease
D. James Surmeier et al.
CELL CALCIUM (2010)
The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy
S. Michiorri et al.
CELL DEATH AND DIFFERENTIATION (2010)
Vps35 Mediates Vesicle Transport between the Mitochondria and Peroxisomes
Emelie Braschi et al.
CURRENT BIOLOGY (2010)
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
Frits Kamp et al.
EMBO JOURNAL (2010)
Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
I. Irrcher et al.
HUMAN MOLECULAR GENETICS (2010)
Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin
Atsushi Tanaka et al.
JOURNAL OF CELL BIOLOGY (2010)
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL
Seok Min Jin et al.
JOURNAL OF CELL BIOLOGY (2010)
PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy
Noriyuki Matsuda et al.
JOURNAL OF CELL BIOLOGY (2010)
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
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NATURE CELL BIOLOGY (2010)
Progression of subtle motor signs in PINK1 mutation carriers with mild dopaminergic deficit
C. Eggers et al.
NEUROLOGY (2010)
The Mitochondrial Fusion-Promoting Factor Mitofusin Is a Substrate of the PINK1/Parkin Pathway
Angela C. Poole et al.
PLOS ONE (2010)
PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
Cristofol Vives-Bauza et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Drosophila Parkin requires PINK1 for mitochondrial translocation and ubiquitinates Mitofusin
Elena Ziviani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
DJ-1 is critical for mitochondrial function and rescues PINK1 loss of function
Ling-Yang Hao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
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PLOS BIOLOGY (2010)
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
Javier Alegre-Abarrategui et al.
HUMAN MOLECULAR GENETICS (2009)
Mitochondrial import and accumulation of α-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
Latha Devi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra et al.
JOURNAL OF CELL BIOLOGY (2008)
Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)
Ryan D. Mills et al.
JOURNAL OF NEUROCHEMISTRY (2008)
LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease
J. Alegre-Abarrategui et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2008)
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
Nicole Exner et al.
JOURNAL OF NEUROSCIENCE (2007)
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
Helene Plun-Favreau et al.
NATURE CELL BIOLOGY (2007)
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
Julia W. Pridgeon et al.
PLOS BIOLOGY (2007)
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David Sulzer
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Lilach Ephraty et al.
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Pesticide exposure exacerbates α-synucleinopathy in an A53T transgenic mouse model
Erin H. Norris et al.
AMERICAN JOURNAL OF PATHOLOGY (2007)
Localization of LRRK2 to membranous and vesicular structures in mammalian brain
Saskia Biskup et al.
ANNALS OF NEUROLOGY (2006)
PINK1 homozygous W437X mutation in a patient with apparent dominant transmission of Parkinsonism
Chiara Criscuolo et al.
MOVEMENT DISORDERS (2006)
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused inactivation of Drosophila Pink1 is rescued by by Parkin
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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
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Lewy body Parkinson's disease in a large pedigree with 77 Parkin mutation carriers
PP Pramstaller et al.
ANNALS OF NEUROLOGY (2005)
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Y Li et al.
NEUROLOGY (2005)
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability
A Beilina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
How does parkin ligate ubiquitin to Parkinson's disease? First in molecular medicine review series
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EMBO REPORTS (2004)
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SCIENCE (2004)
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JC Greene et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Lewy bodies and parkinsonism in families with parkin mutations
M Farrer et al.
ANNALS OF NEUROLOGY (2001)
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway
M Unoki et al.
ONCOGENE (2001)
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CR Haft et al.
MOLECULAR BIOLOGY OF THE CELL (2000)
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
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NATURE GENETICS (2000)
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NEW ENGLAND JOURNAL OF MEDICINE (2000)
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