期刊
JOURNAL OF PARKINSONS DISEASE
卷 7, 期 4, 页码 569-576出版社
IOS PRESS
DOI: 10.3233/JPD-171176
关键词
Aggregation; alpha-synuclein; biomarker; exosome; LRRK2; neurodegeneration
资金
- Wellcome Trust [097479/Z/11/Z, 097479/Z/11/A]
- European Union [116060]
- ARUK
- BMA
- Oxford Biomedical Research Centre
- EPSRC [EP/M006204/1]
Extracellular vesicles including exosomes are released by a variety of cell types including neurons and exhibit molecular profiles that reflect normal and disease states. As their content represents a snapshot of the intracellular milieu, they could be exploited as biomarkers of the otherwise inaccessible brain microenvironment. In addition they may contribute to the progression of neurodegenerative disorders by facilitating the spread of misfolded proteins at distant sites or activating immune cells. This review summarizes recent advances in the study of exosomes in Parkinson's disease pathophysiology and their potential as disease biomarkers.
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