期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 56, 期 16, 页码 4565-4568出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201700840
关键词
amino acids; molecular diversity; multicomponent reactions; tandem reactions; ynamides
资金
- National Natural Science Foundation of China [21472163]
Multicomponent reactions are excellent tools for rapid generation of small molecules with broad chemical diversity and molecular complexity. Herein, a novel one-pot multicomponent synthesis of beta-amino amides from aldehydes, anilines, carboxylic acids and ynamides has been successfully developed. This process is practical and efficient to unravel synthetic utility and scalability. Moreover, an isotope labeling reaction was conducted to elucidate a plausible reaction mechanism.
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