期刊
CHEMICAL COMMUNICATIONS
卷 53, 期 28, 页码 3982-3985出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc01377a
关键词
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资金
- ACT-C program from JST
- JSPS KAKENHI [JP24245019, JP24685006, JP25109519, JP15H00926, JP15H05800]
- Grants-in-Aid for Scientific Research [15H05800, 17H06143, 24685006, 15KT0059] Funding Source: KAKEN
A PGeP-pincer palladium-catalyzed hydrocarboxylation of styrenes to obtain pharmaceutically important alpha-arylpropionic acid derivatives was achieved using a formate salt as both a reductant and a CO2 source. The reaction was also applicable to vinylsulfone and acrylates. Isotope labeling experiments demonstrated that a CO2-recycling mechanism is operative through generation and reaction of a benzylpalladium complex as a carbon nucleophile. This protocol has realized a mild and atom economical CO2-fixation reaction without the necessity of using strong metallic reductants.
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