期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2015, 期 8, 页码 1719-1726出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201403656
关键词
Synthetic methods; Homogeneous catalysis; Aromatic substitution; Arenes; Fluorine; Copper
资金
- INSA Rouen, Rouen University
- Centre National de la Recherche Scientifique (CNRS)
- European Fund for Regional Development (EFRD)
- Labex SynOrg [ANR-11-LABX-0029]
- Region Haute-Normandie (CRUNCh network)
- Ministere de l'Enseignement Superieur et de la Recherche (MESR)
We report the direct introduction of the CF2CO2Et moiety into electron-rich arenes. The copper-catalyzed process uses commercially available and inexpensive BrCF2CO2Et as a fluorinated building block. This radical-free reaction proceeds smoothly to give the desired difluoromethylated arenes in modest to good yields with a Friedel-Crafts-type regioselectivity. The direct introduction of ,-difluoromethylated amides was also investigated, and this gave the corresponding difluoromethylated arenes, albeit in moderate yields. This method represents the first transition-metal-catalyzed direct introduction of a functionalized fluorinated moiety into electron-rich arenes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据