期刊
BMB REPORTS
卷 50, 期 3, 页码 126-131出版社
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2017.50.3.190
关键词
CNS injury; Development; Neuron; P48Ebp1; Regeneration
资金
- National Research Foundation of Korea (NRF) grant - Korean government (MSIP) [NRF-2013R1A2A2A01005324]
- Samsung Biomedical Research Institute grant [SMX1161311]
- Basic Science Research Program through the National Research Foundation of Korea(NRF) - Ministry of Education [2016R1A6A3A11931078]
- National Research Foundation of Korea [2016R1A6A3A11931078] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
P48 Ebp1 is expressed in rapidly proliferating cells such as cancer cells and accelerates cell growth and survival. However, its expression pattern and role in central nervous system development have not been studied. Here, we demonstrated the spatiotemporal expression pattern of p48 Ebp1 during embryonic development and the postnatal period. During embryonic development, p48 Ebp1 was highly expressed in the brain. Expression gradually decreased after birth but was still more abundant than p42 expression after birth. Strikingly, we found that p48 Ebp1 was expressed in a cell type specific manner in neurons but not astrocytes. Moreover, p48 Ebp1 physically interacted with beta tubulin but not alpha tubulin. This fits with its accumulation in distal microtubule growth cone regions. Furthermore, in injured hippocampal slices, p48 Ebp1 introduction promoted axon regeneration. Thus, we speculate that p48 Ebp1 might contribute to microtubule dynamics acting as an MAP and promotes CNS axon regeneration.
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