期刊
CLINICA CHIMICA ACTA
卷 466, 期 -, 页码 133-137出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2016.12.024
关键词
Fetal abnormalities; Triclosan; Triclocarban; Umbilical cord blood
资金
- National Natural Science Foundation of China [21177014]
- Beijing Natural Science Foundation [7142026]
- Beijing Municipal Science & Technology Commission [Z141107002514006]
- Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20151302]
Triclosan (TCS) and triclocarban (TCC) are widely used as antimicrobial compounds in consumer products. TCS and TCC are frequently found in waste water and sewage. In this study, we investigate the potential impact of exposure to triclosan (TCS) and triclocarban (TCC) on fetal abnormalities. We measured TCS and TCC levels in maternal and umbilical cord blood samples from 39 pregnant women diagnosed with fetal or post-birth abnormalities at Beijing Obstetrics and Gynecology Hospital. 52 pregnant women who gave birth to healthy neonates during the same period of time were included as controls. Applying ultra-performance liquid chromatography-tandem mass spectrometry, TCS and TCC concentrations were measured in maternal and fetal sera. Significantly increased levels of TCS were detected in maternal sera from mothers with abnormal births. Similar levels of TCS or TCC were found in maternal and cord sera in control group. The concentrations of TCS or TCC in maternal sera correlated with those in umbilical cord sera (r = 0.649, P < 0.01). These observations suggest that maternal blood test could be a useful assay for detecting fetal exposure to TCS and TCC, and high exposure to TCS may be potentially associated with increased risk for fetal malformations. (C) 2016 Elsevier B.V. All rights reserved.
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