期刊
JOURNAL OF GINSENG RESEARCH
卷 41, 期 2, 页码 127-133出版社
KOREAN SOC GINSENG
DOI: 10.1016/j.jgr.2016.02.001
关键词
anti-inflammatory activity; ginsenoside Rc; p38; Panax ginseng; TANK-binding kinase 1
资金
- Korean Society of Ginseng - Korean Ginseng Corporation (KGC)
Background: Ginsenoside Rc (G-Rc) is one of the major protopanaxadiol-type saponins isolated from Panax ginseng, a well-known medicinal herb with many beneficial properties including anticancer, anti-inflammatory, antiobesity, and antidiabetic effects. In this study, we investigated the effects of G-Rc on inflammatory responses in vitro and examined the mechanisms of these effects. Methods: The in vitro inflammation system used lipopolysaccharide-treated macrophages, tumor necrosis factor-alpha/interferon-gamma-treated synovial cells, and HEK293 cells transfected with various inducers of inflammation. Results: G-Rc significantly inhibited the expression of macrophage-derived cytokines, such as tumor necrosis factor-alpha and interleukin-1 beta. G-Rc also markedly suppressed the activation of TANK-binding kinase 1/I kappa B kinase epsilon/interferon regulatory factor-3 and p38/ATF-2 signaling in activated RAW264.7 macrophages, human synovial cells, and HEK293 cells. Conclusion: G-Rc exerts its anti-inflammatory actions by suppressing TANK-binding kinase 1/I kappa B kinase epsilon/interferon regulatory factor-3 and p38/ATF-2 signaling. (C) 2017 The Korean Society of Ginseng, Published by Elsevier Korea LLC.
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