期刊
CLINICA CHIMICA ACTA
卷 466, 期 -, 页码 78-84出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cca.2016.12.023
关键词
Apelin; APJ; Angiogenesis-related diseases
资金
- National Natural Science Foundation of China [81470434, 81503074, 81670265]
- Hunan Provincial Science and Technology Project [2015RS4040]
- Administration of Traditional Chinese Medicine of Hunan Province [201578]
- Health and Family planning commission of Hunan Province [B2015-48]
Apelin is the endogenous ligand of the G protein-coupled receptor APJ. Both Apelin and APJ receptor are widely distributed in various tissues such as heart, brain, limbs, retina and liver. Recent research indicates that the Apelin/APJ system plays an important role in pathological angiogenesis which is a progress of new blood branches developing from preexisting vessels via sprouting. In this paper, we review the important role of the Apelin/APJ system in pathological angiogenesis. The Apelin/APJ system promotes angiogenesis in myocardial infarction, ischemic stroke, critical limb ischemia, tumor, retinal angiogenesis diseases, cirrhosis, obesity, diabetes and other related diseases. Furthermore, we illustrate the detailed mechanism of pathological angiogenesis induced by the Apelin/APJ system. In conclusion, the Apelin/APJ system would be a promising therapeutic target for angiogenesis-related diseases. (C) 2016 Elsevier B.V. All rights reserved.
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