期刊
JOURNAL OF DIABETES
卷 9, 期 11, 页码 1040-1047出版社
WILEY
DOI: 10.1111/1753-0407.12523
关键词
association; CA 19-9; metabolic syndrome
资金
- National Natural Science Foundation of China [81370960, 81670795]
- Ministry of Science and Technology of the People's Republic of China [2015BAI12B14, 2015BAI12B02, 2016YFC0901200, 2016YFC1305202]
- Chenxing Plan of Shanghai Jiaotong University
- Shuguang Program [15SG15]
- Shanghai Municipal Education Commission [20152202]
BackgroundIncreasing evidence suggests that serum CA 19-9 is associated with abnormal glucose metabolism. However, data on the association between CA 19-9 and metabolic syndrome is limited. The aim of the present study was to investigate the association between serum CA 19-9 and metabolic syndrome. MethodsA cross-sectional study was conducted on 3641 participants aged 40years from the Songnan Community, Baoshan District in Shanghai, China. Logistic regression analysis was used to evaluate the association between serum CA 19-9 and metabolic syndrome. ResultsMultivariate logistic regression analysis showed that compared with participants in the first tertile of serum CA 19-9, those in the second and third tertiles had increased odds ratios (OR) for prevalent metabolic syndrome (multivariate adjusted OR 1.46 [95% confidence interval {CI} 1.11-1.92] and 1.51 [95% CI 1.14-1.98]; P-trend=0.005). In addition, participants with elevated serum CA 19-9 (37U/mL) had an increased risk of prevalent metabolic syndrome compared with those with serum CA 19-9< 37U/mL (multivariate adjusted OR 2.10; 95% CI 1.21-3.65). ConclusionSerum CA 19-9 is associated with an increased risk of prevalent metabolic syndrome. In order to confirm this association and identify potential mechanisms, prospective cohort and mechanic studies should be performed.
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