期刊
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
卷 7, 期 10, 页码 1000-1007出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jbt.2017.1657
关键词
Graphene Oxide; Collagen; Nano-Hydroxyapatite; Osteoblasts
资金
- National Natural Science Foundation of China [81501576, 51303028]
- Nature Science Foundation of Jiangsu Province [BK20130266, BL2013015]
- Natural Science Foundation of Fujian Province [2015J01341, 2017J01482]
We present the synthesis of graphene oxide (GO) via the modified Hummer method and nanocomposites based on collagen/ nano-hydroxyapatite (COL/nHA). GO was prepared by freeze drying the stable mixture of the components. Comprehensive characterizations of the properties of GO were conducted by X-ray diffraction and Fourier-transform infrared spectra analyzer. Effects of the incorporation of GO on morphology, phase structure, and wear resistance of the resulting composite coatings were evaluated in detail. FT-IR results show that the GO and nHA disperse homogeneously in the composite. COL/GO/nHA composites with high porosity were confirmed by scanning electron microscope and porosity test. By increasing the GO content from 0 to 4 wt%, COL/GO/nHA composites exhibited improved hydrophilic and mechanical properties. The cell viability and proliferation results showed that osteoblastic cells can adhere and develop on COL/GO/nHA composites. An outstanding proliferation potential was displayed by the cells in contact with COL/GO/nHA 4 wt%. The GO-reinforced COL/nHAs with high mechanical and bioactive properties are potential candidates for bone tissue engineering.
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