期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 312, 期 3, 页码 H608-H621出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00575.2016
关键词
autonomic nervous system; sympathetic nerves; conduction velocity; electrical propagation; ventricular arrhythmias
资金
- National Heart, Lung, and Blood Institute [HL-125730, HL-084261]
- National Institute of General Medical Sciences Center for Integrative Biomedical Computing
- University of Utah [2P41RR0112553-2]
The influence of cardiac sympathetic innervation on electrical activation in normal and chronically infarcted ventricular myocardium is not understood. Yorkshire pigs with normal hearts (NL, n = 12) or anterior myocardial infarction (MI, n = 9) underwent high-resolution mapping of the anteroapical left ventricle at baseline and during left and right stellate ganglion stimulation (LSGS and RSGS, respectively). Conduction velocity (CV), activation times (ATs), and directionality of propagation were measured. Myocardial fiber orientation was determined using diffusion tensor imaging and histology. Longitudinal CV (CVL) was increased by RSGS (0.98 +/- 0.11 vs. 1.2 +/- 0.14m/s, P < 0.001) but not transverse CV (CVT). This increase was abrogated by beta-adrenergic receptor and gap junction (GJ) blockade. Neither CVL nor CVT was increased by LSGS. In the peri-infarct region, both RSGS and LSGS shortened ARIs in sinus rhythm (423 +/- 37 vs. 322 +/- 30 ms, P < 0.001, and 423 +/- 36 vs. 398 +/- 36 ms, P = 0.035, respectively) and altered activation patterns in all animals. CV, as estimated by mean ATs, increased in a directionally dependent manner by RSGS (14.6 +/- 1.2 vs. 17.3 +/- 1.6 ms, P = 0.015), associated with GJ lateralization. RSGS and LSGS inhomogeneously modulated AT and induced relative or absolute functional activation delay in parts of the mapped regions in 75 and 67%, respectively, in MI animals, and in 0 and 15%, respectively, in control animals ( P < 0.001 for both). In conclusion, sympathoexcitation increases CV in normal myocardium and modulates activation propagation in peri-infarcted ventricular myocardium. These data demonstrate functional control of arrhythmogenic periinfarct substrates by sympathetic nerves and in part explain the temporal nature of arrhythmogenesis. NEW & NOTEWORTHY This study demonstrates regional control of conduction velocity in normal hearts by sympathetic nerves. In infarcted hearts, however, not only is modulation of propagation heterogeneous, some regions showed paradoxical conduction slowing. Sympathoexcitation altered propagation in all infarcted hearts studied, and we describe the temporal arrhythmogenic potential of these findings. Listen to this article's corresponding podcast at http://ajpheart. podbean.com/e/sympathetic-nerves-and-cardiac-propagation/.autonomic nervous system; sympathetic nerves; conduction velocity; electrical propagation; ventricular arrhythmias
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据