Palladium-Catalyzed Domino Mizoroki-Heck/Intermolecular C(sp3)-H Activation Sequence: An Approach to the Formation of C(sp3)-C(sp3) Bonds

A palladium-catalyzed domino Mizoroki-Heck/intermolecular unactivated C(sp(3))-H alkylation reaction has been developed. This simple palladium nanoparticle catalytic system shows good activity and affords the dimeric dihydrobenzofuran derivatives in moderate to good yields. Furthermore, this reaction provides a new method for the elaboration of domino reactions involving a C(sp(3))-C(sp(3)) bond-forming process.