期刊
CHROMOSOME RESEARCH
卷 25, 期 1, 页码 51-60出版社
SPRINGER
DOI: 10.1007/s10577-017-9550-3
关键词
Cohesin; CTCF; Chromosomal domain; Loop extrusion
资金
- Wellcome Trust [106985/Z/15/Z]
- EPIGENESYS EU NoE
- Wellcome Trust [106985/Z/15/Z] Funding Source: Wellcome Trust
Extensive research has revealed that cohesin acts as a topological device, trapping chromosomal DNA within a large tripartite ring. In so doing, cohesin contributes to the formation of compact and organized genomes. How exactly the cohesin subunits interact, how it opens, closes, and translocates on chromatin, and how it actually tethers DNA strands together are still being elucidated. A comprehensive understanding of these questions will shed light on how cohesin performs its many functions, including its recently proposed role as a chromatid loop extruder. Here, we discuss this possibility in light of our understanding of the molecular properties of cohesin complexes.
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