期刊
CHEMICAL ENGINEERING RESEARCH & DESIGN
卷 119, 期 -, 页码 221-230出版社
INST CHEMICAL ENGINEERS
DOI: 10.1016/j.cherd.2017.01.024
关键词
Starch aerogel; Supercritical adsorption; Vitamin K; Vitamin E; Dissolution profiles; Adsorption mechanisms
资金
- MIUR (Italian Ministry of Scientific Research)
Maize starch aerogel (MSA), a biocompatible and biodegradable support, was loaded with a-tocopherol (vitamin E) and menadione (vitamin K-3), two poorly water-soluble vitamins using supercritical carbon dioxide adsorption. Adsorption experiments were carried out at 15 MPa and 40 and 60 degrees C. Adsorption equilibrium data were measured and represented as isotherms. Kinetic data, related to adsorption rates, showed that the adsorption process, for both vitamins, was best described by a pseudo second-order model. Vitamin/MSA composites were characterized using FT-IR spectroscopy, X-ray diffractometry and specific surface area determination. In order to study the properties of the adsorbed MSA, as a vitamin delivery system, in vitro dissolution tests were performed. These analyses showed that vitamin loading was about 95-98% with respect to the expected concentration, for both the cases. The dissolution rate in phosphate buffered saline solution (PBS) was largely improved: it was 3.5 times faster than the one of unprocessed vitamin in the case of menadione and about 16 times faster in the case of a-tocopherol. (C) 2017 Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据