期刊
ACS NANO
卷 11, 期 3, 页码 2961-2971出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.6b08390
关键词
nerve electrode; flexible device; neural interfacing; electrospun nanofiber; inkjet printing
类别
资金
- Public Welfare & Safety research program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2012R1A5A2051388]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health Welfare [HI14C2241]
- Basic Science Research Program through the NRF - Ministry of Science, ICT & Future Planning [NRF-2014R1A1A3052557]
- KIST Institutional Program [2E26180]
Polyimide (PI)-based electrodes have been widely used as flexible biosensors in implantable device appliCations for recording biological signals. However, the long-term quality of neural signals obtained from PI-based nerve electrodes tends to decrease due to nerve damage by neural tissue compression, mechanical mismatch, and insufficient fluid exchange between the neural tissue and electrodes. Here, we resolve these problems with a developed PI nanofiber (NF)-based nerve electrode for stable neural signal recording, which can be fabricated via electrospinning and inkjet printing. We demonstrate an NF-based nerve electrode that can be simply fabricated and easily applied due to its high permeability, flexibility, and biocompatibility. Furthermore, the electrode can record stable neural signals for extended periods of time, resulting in decreased mechanical mismatch, neural compression, and contact area. NF-based electrodes with highly flexible and body-fluid-permeable properties could enable future neural interfacing applications.
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