期刊
BIOLOGICAL PSYCHOLOGY
卷 124, 期 -, 页码 111-118出版社
ELSEVIER
DOI: 10.1016/j.biopsycho.2017.01.014
关键词
Carbon dioxide hypersensitivity; Panic risk; Temporal stability; Reliability; Subjective anxiety; Respiratory rate; Heart rate; Skin conductance; Panic attack; Panic symptoms
资金
- NIMH [R34MH106770]
- Templeton Science of Prospection Award
- [NIMHK01MH080953]
Self-reported anxiety, and potentially physiological response, to maintained inhalation of carbon dioxide (CO2) enriched air shows promise as a putative marker of panic reactivity and vulnerability. Temporal stability of response systems during low-dose, steady-state CO2 breathing challenge is lacking. Outcomes on multiple levels were measured two, times, one week apart, in 93 individuals. Stability was highest during the CO2 breathing phase compared to pre-CO2 and recovery phases, with anxiety ratings, respiratory rate, skin conductance level, and heart rate demonstrating good to excellent temporal stability (ICCS > 0.71). Cognitive symptoms tied to panic were somewhat less stable (ICC = 0.58) than physical symptoms (ICC = 0.74) during CO2 breathing. Escape/avoidance behaviors and DSM-5 panic attacks were not stable. Large effect sizes between task phases also were observed. Overall, results suggest good-excellent levels of temporal stability.for multiple outcomes during respiratory stimulation via 7.5% CO2. (C) 2017 Elsevier B.V. All rights reserved.
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