期刊
EMBO MOLECULAR MEDICINE
卷 9, 期 4, 页码 448-461出版社
WILEY
DOI: 10.15252/emmm.201606932
关键词
faecal microbiota transplantation; gastrointestinal toxicity; gut microbiota; radiation syndrome; radiotherapy
资金
- National Natural Science Foundation of China [81502664, 81572969, 81402541]
- CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-017]
- PUMC Youth Fund
- Fundamental Research Funds for the Central Universities [33320140187, 3332016099, 3332016143]
- IRM-CAMS Research Fund [1547, 1522]
- Technology and Development and Research Projects for Research Institutes, Ministry of Science and Technology [2014EG150134]
- Tianjin Science and Technology Support Plan Project (TJKJZC) [14ZCZDSY00001]
- U.S. National Center for Complementary and Alternative Medicine (NCCAM) [R01AT005076]
- National Institute of General Medical Sciences (NIGMS) [R01GM063075]
Severe radiation exposure may cause acute radiation syndrome, a possibly fatal condition requiring effective therapy. Gut microbiota can be manipulated to fight against many diseases. We explored whether intestinal microbe transplantation could alleviate radiation- induced toxicity. High-throughput sequencing showed that gastrointestinal bacterial community composition differed between male and female mice and was associated with susceptibility to radiation toxicity. Faecal microbiota transplantation (FMT) increased the survival rate of irradiated animals, elevated peripheral white blood cell counts and improved gastrointestinal tract function and intestinal epithelial integrity in irradiated male and female mice. FMT preserved the intestinal bacterial composition and retained mRNA and long non-coding RNA expression profiles of host small intestines in a sex-specific fashion. Despite promoting angiogenesis, sex-matched FMT did not accelerate the proliferation of cancer cells in vivo. FMT might serve as a therapeutic to mitigate radiation-induced toxicity and improve the prognosis of tumour patients after radiotherapy.
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