期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 25, 期 4, 页码 1514-1523出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2017.01.014
关键词
Atom economy; Spirocyclohexanone; Oxindole; Pyrrolidine; 1,3-Dipolar cycloaddition; Azomethine ylide; Breast cancer; Leukemia; Molecular docking
资金
- Deanship of Scientific Research at King Saud University [RGP-257]
The 1,3-dipolar cycloadditions of an azomethine ylide generated from isatin and thiazolidinecarboxylic acid to a series of 2,6-bis[(E)-arylmethylidene]cyclohexanones afforded new di-spiro heterocycles incorporating pyrrolidine and oxindole rings in quantitative yields and chemo-, regio-, and stereoselectively. The newly synthesized compounds were characterized using spectroscopic techniques. Furthermore, the molecular structures of 4a, 4e, and 4n were confirmed by X-ray crystallography. These newly synthesized compounds were screened for their in vitro activity against breast cancer cell line MCF-7 and K562-leukemia. 4k was found to be the most potent compound of this series in targeting MCF-7 breast cancer cells and K562-leukemia, with IC50 values of 15.32 +/- 0.02 and 14.74 +/- 0.7 mu M, respectively. The molecular studies of the synthesized compounds were investigated. (C) 2017 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据