期刊
BIOSENSORS & BIOELECTRONICS
卷 91, 期 -, 页码 870-877出版社
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2017.01.062
关键词
pH; Temperature; Graphene; Flexible sensor
类别
资金
- EU [FP7 ICT-317894]
- Ente Cassa di Risparmio di Firenze
Point-of-care applications and patients' real-time monitoring outside a clinical setting would require disposable and durable sensors to provide better therapies and quality of life for patients. This paper describes the fabrication and performances of a temperature and a pH sensor on a biocompatible and wearable board for healthcare applications. The temperature sensor was based on a reduced graphene oxide (rGO) layer that changed its electrical resistivity with the temperature. When tested in a human serum sample between 25 and 43 C-omicron, the sensor had a sensitivity of 110 +/- 10 Omega/ C-omicron and an error of 0.4 +/- 0.1 C-omicron compared with the reference value set in a thermostatic bath. The pH sensor, based on a graphene oxide (GO) sensitive layer, had a sensitivity of 40 4 mV/pH in the pH range between 4 and 10. Five sensor prototypes were tested in a human serum sample over one week and the maximum deviation of the average response from reference values obtained by a glass electrode was 0.2 pH units. For biological applications, the temperature and pH sensors were successfully tested for in vitro cytotoxicity with human fibroblast cells (MRC-5) over 24 h.
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