期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 359, 期 7, 页码 1131-1137出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201700095
关键词
asymmetric synthesis; enzyme catalysis; hydroxydioxinones; ketoreductases
资金
- NIGMS/NIH [T32GM105538]
A novel biocatalytic system to access a wide variety of beta-hydroxydioxinones from beta-ketodioxinones employing commercial engineered ketoreductases has been developed. This practical system provides a remarkably straightforward solution to limitations in accessing certain chemical scaffolds common in beta-hydroxydioxinones that are of great interest due to their diversification capabilities. A few highlights of this system are that it is high yielding, highly enantioselective, and chromatography-free. We have demonstrated both a wide substrate scope and a high degree of scalability
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