期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 312, 期 4, 页码 H701-H704出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00790.2016
关键词
cerebrovascular blood flow; exercise; hypertension; hypotension; hysteresis
资金
- Ministere de l'Education, du Loisir et du Sport du Quebec
- Foundation of the Institut Universitaire de Cardiologie et de Pneumologie de Quebec
- Natural Sciences and Engineering Research Council of Canada Discovery grant
- Killam predoctoral fellowship
The cerebrovasculature is more efficient at compensating for pharmacologically induced transient hypertension versus transient hypotension. Whether this phenomenon exists during nonpharmacologically induced hypertension and hypotension is currently unknown. We compared the percent change in mean velocity in the middle cerebral artery (MCAvmean) per percent change in mean arterial pressure (MAP) (%Delta MCAVmean/%Delta MAP) during transient hypertension and hypotension induced during squatstand maneuvers performed at 0.05 Hz (20-s cycles) and 0.10 Hz (10-s cycles) in 58 male volunteers. %Delta MCAvmean/%Delta MAP was attenuated by 25% (P = 0.03, 0.05 Hz) and 47% (P < 0.0001, 0.10 Hz) during transient hypertension versus hypotension. Thus, these findings indicate that the brain in healthy men is better adapted to compensate for physiologically relevant transient hypertension than hypotension. NEW & NOTEWORTHY The novel finding of this study is that the change in middle cerebral artery mean flow velocity is attenuated during hypertension compared with hypotension physiologically induced by oscillations in blood pressure in men. These results support that the human brain is more effective at compensating for transient hypertension than hypotension.
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