期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
卷 1861, 期 4, 页码 824-838出版社
ELSEVIER
DOI: 10.1016/j.bbagen.2016.12.022
关键词
Snake venoms; Toxins; Drug discovery
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP, Sao Paulo Research Foundation) [2011/23236-4, 2014/06170-8, 2013/26619-7, 2015/16714-8, 2014/15644-3, 2013/26200-6, 2012/13590-8, 2012/12954-6, 2011/12317-3]
- Conelho Nacional de Desenvolvimento Cientifico (CNPQ, The National Council for Scientific and Technological Development) [303689/2013-7, 140949/2015-1]
- Cordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES, Coordination for the Improvement of Higher Education Personnel)
- Support Nucleus for Research on Animal Toxins (NAP-TOXAN-USP) [12-125432.1.3]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [12/13590-8, 15/16714-8] Funding Source: FAPESP
Snake venoms present a great diversity of pharmacologically active compounds that may be applied as research and biotechnological tools, as well as in drug development and diagnostic tests for certain diseases. The most abundant toxins have been extensively studied in the last decades and some of them have already been used for different purposes. Nevertheless, most of the minor snake venom protein classes remain poorly explored, even presenting potential application in diverse areas. The main difficulty in studying these proteins lies on the impossibility of obtaining sufficient amounts of them for a comprehensive investigation. The advent of more sensitive techniques in the last few years allowed the discovery of new venom components and the indepth study of some already known minor proteins. This review summarizes information regarding some structural and functional aspects of low abundant snake venom proteins classes, such as growth factors, hyaluronidases, cysteine-rich secretory proteins, nucleases and nucleotidases, cobra venom factors, vespryns, protease inhibitors, antimicrobial peptides, among others. Some potential applications of these molecules are discussed herein in order to encourage researchers to explore the full venom repertoire and to discover new molecules or applications for the already known venom components.(C) 2016 Published by Elsevier B.V.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据