期刊
HUMAN VACCINES & IMMUNOTHERAPEUTICS
卷 13, 期 6, 页码 1398-1403出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/21645515.2017.1285477
关键词
cancer vaccine; DNA vaccine; idiotype; lymphoma; polyethylenimine
资金
- Belarus Ministry of Health [20142755]
We report on the design of a phase I, non-randomized, open-label study of idiotypic DNA vaccination in patients with B-cell non-Hodgkin's lymphoma (ISRCTN31090206). The study uses DNA fusion gene vaccination encoding patient-specific single chain variable fragment, or idiotype, linked to an immunostimulatory sequence. Two types of immunostimulatory sequence are being explored: potato virus X coat protein and human chemokine MIP3. Linear polyethylenimine with low molecular weight (8 kDa) is used as a synthetic vehicle for vaccine delivery. Humoral and T-cellular immune responses to vaccination will be measured by ELISA and ELISPOT, respectively. The primary study endpoints are safety, tolerability and immunogenicity of DNA-PEI vaccination.
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