期刊
BIOTECHNOLOGY LETTERS
卷 39, 期 4, 页码 491-499出版社
SPRINGER
DOI: 10.1007/s10529-016-2275-0
关键词
Fluorescent dye; IR-822-Met; L-Methionine; Near-infrared fluorescence imaging; Tumor diagnosis
资金
- Shandong Provincial Natural Science Foundation, China [ZR2016BL16, ZR2016CL01]
- National High-tech Research and Development Project [2013AA032205]
- Industry Project of Jiangsu Science-Technology [BE2013840]
- Science and Technology Development Program of Suzhou [ZXY201412]
Objective Methionine is a valid target for the treatment of cancer and to achieve in vivo imaging and early diagnosis of tumors, we have synthesized near-infrared (NIR) fluorochrome IR-822-labeled methionine (IR-822-Met). Results NIR fluorescent dye IR-822 was conjugated with methionine through its amide bond. It had low toxicity to normal cell/tissues. In vitro and in vivo studies demonstrated its high targeting capability to tumors. The results support the potential of using ligand-modified methionine probe for tumor diagnosis and targeted therapy. The probe also exhibited good photostability, and excellent cell membrane permeability. Conclusion IR-822-Met is a promising imaging agent for tumor diagnosis, especially in their early stage.
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