期刊
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
卷 173, 期 4, 页码 978-984出版社
WILEY
DOI: 10.1002/ajmg.a.38105
关键词
somatic mosaicism; PIK3CA; PIK3CA-related; overgrowth spectrum
资金
- SK Yee Medical Research Fund
- Society for the Relief of Disabled Children
- HKU Seed Funding for Basic Research
Somatic mutations in PIK3CA cause many overgrowth syndromes that have been recently coined the PIK3CA-Related Overgrowth Spectrum. Here, we present seven molecularly confirmed patients with PIK3CA-Related Overgrowth Spectrum, including patients with Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, Scoliosis/Skeletal and Spinal syndrome, Klippel-Trenaunay syndrome, lymphatic malformation and two with atypical phenotypes that cannot be classified into existing disease categories. The literature on PIK3CA-Related Overgrowth Spectrum, suggests that PIK3CA c. 1258T>C; p.(Cys420Arg), c. 1624G>A; p.(Glu542Lys), c. 1633G>A; p.(Glu545Lys), c. 3140A>G; p.(His1047Arg), and c. 3140A>T; p.(His1047Leu) can be identified in approximately 90% of patients without brain overgrowth. Therefore, droplet digital polymerase chain reaction targeting these mutation hot-spots could be used as the first-tier genetic test on patients with PIK3CA-Related Overgrowth Spectrum who do not have signs of overgrowth in their central nervous system. (C) 2017 Wiley Periodicals, Inc.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据