期刊
AGING-US
卷 9, 期 3, 页码 778-789出版社
IMPACT JOURNALS LLC
DOI: 10.18632/aging.101191
关键词
aging; senescence; microvesicles; vascular calcification; endothelial cells; vascular smooth muscle cells
资金
- Plan Nacional Proyectos de Investigacion en Salud of Instituto de Salud Carlos III (ISCIII) Fondos Feder European Grants [PI11/01536, PI12/01489, PI14/00806, PI15/01785]
- Red de Investigacion Renal [RD16/0009/0034]
- Junta de Andalucia Grants [P010-CTS-6337, P11-CTS7352]
- program Ayuda Postdoctoral Programa Propio from Universidad de Alcala, Madrid, Spain
- Consejeria de Innovacion, Ciencia y Empresa, Junta de Andalucia [CTS-6337, P11-CTS-7352]
Vascular calcification is commonly seen in elderly people, though it can also appear in middle-aged subjects affected by premature vascular aging. The aim of this work is to test the involvement of microvesicles (MVs) produced by senescent endothelial cells (EC) and from plasma of elderly people in vascular calcification. The present work shows that MVs produced by senescent cultured ECs, plus those found in the plasma of elderly subjects, promote calcification in vascular smooth muscle cells. Only MVs from senescent ECs, and from elderly subjects' plasma, induced calcification. This ability correlated with these types of MVs' carriage of: a) increased quantities of annexins (which might act as nucleation sites for calcification), b) increased quantities of bone-morphogenic protein, and c) larger Ca contents. The MVs of senescent, cultured ECs, and those present in the plasma of elderly subjects, promote vascular calcification. The present results provide mechanistic insights into the observed increase in vascular calcification-related diseases in the elderly, and in younger patients with premature vascular aging, paving the way towards novel therapeutic strategies.
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