期刊
G3-GENES GENOMES GENETICS
卷 7, 期 11, 页码 3797-3808出版社
GENETICS SOCIETY AMERICA
DOI: 10.1534/g3.117.300224
关键词
Candida albicans; filamentation; hyphal growth; in vitro model comparisons
资金
- Nebraska Research Initiative (NRI)
- National Institutes of Health (NIH) [2P20GM103427, 5P30CA036727]
- NIH [2P20GM103427]
- University of Nebraska at Omaha
- National Institute for General Medical Science (NIGMS) INBRE grants [P20GM103427-14]
- Fred & Pamela Buffett Cancer Center Support Grant [P30CA036727]
- National Institute for General Medical Science (NIGMS) COBRE grant [1P30GM110768-01]
The ability of the human pathogenic fungus Candida albicans to switch between yeast-like and filamentous forms of growth has long been linked to pathogenesis. Numerous environmental conditions, including growth at high temperatures, nutrient limitation, and exposure to serum, can trigger this morphological switch and are frequently used in in vitro models to identify genes with roles in filamentation. Previous work has suggested that differences exist between the various in vitro models both in the genetic requirements for filamentation and transcriptional responses to distinct filamentation-inducing media, but these differences had not been analyzed in detail. We compared 10 in vitro models for filamentation and found broad genetic and transcriptomic differences between model systems. The comparative analysis enabled the discovery of novel media-independent genetic requirements for filamentation as well as a core filamentation transcriptional profile. Our data also suggest that the physical environment drives distinct programs of filamentation in C. albicans, which has significant implications for filamentation in vivo.
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