期刊
FRONTIERS IN AGING NEUROSCIENCE
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnagi.2017.00327
关键词
Alzheimer disease; amyloid beta-peptides; dementia; inflammation; neurodegenerative diseases; neurofibrillary tangles; periodontal diseases; periodontitis
资金
- Brazilian Government/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- CNPq
- PROPESP-UFPA
Periodontitis is an oral chronic infection/inflammatory condition, identified as a source of mediators of inflammation into the blood circulation, which may contribute to exacerbate several diseases. There is increasing evidence that inflammation plays a key role in the pathophysiology of Alzheimer's disease (AD). Although inflammation is present in both diseases, the exact mechanisms and crosslinks between periodontitis and AD are poorly understood. Therefore, this article aims to review possible comorbidity between periodontitis and AD. Here, the authors discuss the inflammatory aspects of periodontitis, how this oral condition produces a systemic inflammation and, finally, the contribution of this systemic inflammation for worsening neuroinflammation in the progression of AD.
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