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JOURNAL OF THE NEUROLOGICAL SCIENCES (2015)
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Ximena Paez-Colasante et al.
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Rafael Franco et al.
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Niko Hensel et al.
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Yuko Koshimori et al.
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Antonio Conti et al.
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Glial cells in amyotrophic lateral sclerosis
T. Philips et al.
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Lars Toenges et al.
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Ana Borrajo et al.
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Sam Joshva Baskar Jesudasan et al.
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Rene Guenther et al.
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M. Takata et al.
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M. C. Evans et al.
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Carmen Noelker et al.
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Bing Liao et al.
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Jun Yan et al.
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Begona Villar-Cheda et al.
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Jing Ding et al.
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Ayseguel Tura et al.
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Nitrated alpha-synuclein and microglial neuroregulatory activities
Ashley D. Reynolds et al.
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Parkinson's disease: clinical features and diagnosis
J. Jankovic
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Uwe-Karsten Hanisch et al.
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Anna L. Bartels et al.
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J. Rodriguez-Pallares et al.
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Yoshio Suzuki et al.
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Innate immunity in amyotrophic lateral sclerosis
Katie Moisse et al.
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Laurie Erb et al.
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Purinergic signaling and microglia
Katrin Faerber et al.
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Rational design of inhibitors that bind to inactive kinase conformations
Y Liu et al.
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Severine Boillee et al.
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In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
A Gerhard et al.
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A comprehensive map of the toll-like receptor signaling network
Kanae Oda et al.
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K Inoue
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BK Mueller et al.
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W Zhang et al.
FASEB JOURNAL (2005)
Microglial activation and dopamine terminal loss in early Parkinson's disease
Y Ouchi et al.
ANNALS OF NEUROLOGY (2005)
Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs
JK Olson et al.
JOURNAL OF IMMUNOLOGY (2004)
Evidence of active microglia in substantia nigra pars compacta of parkinsonian monkeys 1 year after MPTP exposure
C Barcia et al.
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Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson's disease
HM Gao et al.
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Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging
F Cicchetti et al.
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Function of Rho family proteins in actin dynamics during phagocytosis and engulfment
G Chimini et al.
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