期刊
CANCER CELL
卷 31, 期 4, 页码 532-+出版社
CELL PRESS
DOI: 10.1016/j.ccell.2017.02.017
关键词
-
资金
- Prostate Cancer Foundation Challenge Award
- NIH [R01CA132874]
- Prostate SPORE [P50CA69568]
- Early Detection Research Network [UO1 CA113913]
- Department of Defense [PC051081, PC094725]
- AACR-Bayer Prostate Cancer Research Fellowship [16-40-44-PITC]
- PCF Young Investigator Award
- NIH/NCI [R01CA157845, R01CA154980]
Transcription factors play a key role in the development of diverse cancers, and therapeutically targeting them has remained a challenge. In prostate cancer, the gene encoding the transcription factor ERG is recurrently rearranged and plays a critical role in prostate oncogenesis. Here, we identified a series of peptides that interact specifically with the DNA binding domain of ERG. ERG inhibitory peptides (EIPs) and derived peptidomimetics bound ERG with high affinity and specificity, leading to proteolytic degradation of the ERG protein. The EIPs attenuated ERG-mediated transcription, chromatin recruitment, protein-protein interactions, cell invasion and proliferation, and tumor growth. Thus, peptidomimetic targeting of transcription factor fusion products may provide a promising therapeutic strategy for prostate cancer as well as other malignancies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据