期刊
JOURNAL OF PHYSICS D-APPLIED PHYSICS
卷 50, 期 13, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/1361-6463/aa5c55
关键词
elastin; extracellular matrix; mechanical characterization; multi-photon imaging; piezoelectric force microscopy; nuclear magnetic resonance; vascular remodeling
资金
- National Key Research Program of China [2016YFA0201001]
- National Science Foundation [CMMI 1100791, CMMI 1463390]
- Shenzhen Science and Technology Innovation Committee [ZDSYS20140509162754023, JCYJ20160331191436180]
- National Institute of Health [R01HL098028, 2SC1GM086268]
Elastin, the principle protein component of the elastic fiber, is a critical extracellular matrix (ECM) component of the arterial wall providing structural resilience and biological signaling essential in vascular morphogenesis and maintenance of mechanical homeostasis. Pathogenesis of many cardiovascular diseases have been associated with alterations of elastin. As a long-lived ECM protein that is deposited and organized before adulthood, elastic fibers can suffer from cumulative effects of biochemical exposure encountered during aging and/or disease, which greatly compromise their mechanical function. This review article covers findings from recent studies of the mechanical and structural contribution of elastin to vascular function, and the effects of biochemical degradation. Results from diverse experimental methods including tissue-level mechanical characterization, fiber-level nonlinear optical imaging, piezoelectric force microscopy, and nuclear magnetic resonance are reviewed. The intriguing coupled bio-chemo-electro-mechanical behavior of elastin calls for a multi-scale and multi-physical understanding of ECM mechanics and mechanobiology in vascular remodeling.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据