期刊
CANCER LETTERS
卷 392, 期 -, 页码 83-93出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2017.01.041
关键词
Pancreatic cancer; Tumor microenvironment; Stroma; Crosstalk; Targeted therapy
类别
资金
- Natural Science Foundation of China [81302077]
- China Postdoctoral Science Foundation [2013M531606]
- Shandong Provincial Natural Science Foundation, China [ZR2013HQ049]
Pancreatic cancer (PC) remains one of the most lethal malignancies worldwide. Increasing evidence has confirmed the pivotal role of stromal components in the regulation of carcinogenesis, invasion, metastasis, and therapeutic resistance in PC. Interaction between neoplastic cells and stromal cells builds a specific microenvironment, which further modulates the malignant properties of cancer cells, Instead of being a passive bystander, stroma may play a role as a partner in crime in PC. However, the role of stromal components in PC is complex and requires further investigation. In this article, we review recent advances regarding the regulatory roles and mechanisms of stroma biology, especially the cellular components such as pancreatic stellate cells, macrophages, neutrophils, adipocytes, epithelial cells, pericytes, mast cells, and lymphocytes, in PC. Crosstalk between stromal cells and cancer cells is thoroughly investigated. We also review the prognostic value and molecular therapeutic targets of stroma in PC. This review may help us further understand the molecular mechanisms of stromal biology and its role in PC development and therapeutic resistance. Moreover, targeting stroma components may provide new therapeutic strategies for this stubborn disease. (C) 2017 Elsevier B.V. All rights reserved.
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