期刊
CANCER LETTERS
卷 392, 期 -, 页码 51-59出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2017.01.034
关键词
Mitogen-activated protein kinase; MEK5-ERK5; Cellular signaling; Kinase inhibitors; Targeted therapies
类别
资金
- National Institutes of Health [CA176496, CA125806, CA174785]
- Office of Naval Research [N00014-16-1-1136]
Mitogen-activated protein kinases (MAPKs) regulate diverse cellular processes including proliferation, cell survival, differentiation, and apoptosis. While conventional MAPK constituents have well-defined roles in oncogenesis, the MEK5 pathway has only recently emerged in cancer research. In this review, we consider the MEK5 signaling cascade, focusing specifically on its involvement in drug resistance and regulation of aggressive cancer phenotypes. Moreover, we explore the role of MEK5/ERK5 in tumorigenesis and metastatic progression, discussing the discrepancies in preclinical studies and assessing its viability as a therapeutic target for anti-cancer agents. (C) 2017 Elsevier B.V. All rights reserved.
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