期刊
DIABETES CARE
卷 40, 期 5, 页码 698-701出版社
AMER DIABETES ASSOC
DOI: 10.2337/dc16-2331
关键词
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资金
- National Institutes of Health through the National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of Allergy and Infectious Diseases
- Eunice Kennedy Shriver National Institute of Child Health and Human Development [U01-DK-061010, U01-DK-061034, U01-DK061042, U01-DK-061058, U01-DK-085465, U01-DK-085453, U01-DK-085461, U01-DK085463, U01-DK-085466, U01-DK-085499, U01-DK-085504, U01-DK-085505, U01-DK085509, U01-DK-103180, U01-DK-103153, U01-DK-085476, U01-DK-103266]
- JDRF
- National Institutes of Health [K12-DK-094726, U01-DK-103180-01]
- Type 1 Diabetes TrialNet PTP Study Group
OBJECTIVE We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex- and age-specific ceBMI thresholds for greatest type 1 diabetes risk. RESULTS Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males. CONCLUSIONS Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age.
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