期刊
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
卷 11, 期 7, 页码 651-661出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17474124.2017.1312342
关键词
Gastric cancer; H; pylori; biomarker; early diagnosis; targeted therapy
资金
- National Basic Research Program of China (973 Program) [2010CB529300]
Introduction: Gastric cancer (GC) is a highly aggressive cancer and a major cause of cancer-related deaths worldwide. Approximately half of the world's GC cases and deaths occur in china. GC presents challenges in early diagnosis and effective therapy due to a lack of understanding of the underlying molecular biology. The primary goals of this review are to outline current GC research in china and describe future trends in this field.Areas covered: This review mainly focuses on a series of GC-related advances China has achieved. Considerable progress has been made in understanding the role of H. pylori in GC by a series of population-based studies in well-established high-risk areas; A few germline and somatic alterations have been identified by omics' studies; Studies on the mechanisms of malignant phenotypes have helped us to form an in-depth understanding of GC and advance drug discovery. Moreover, identification of potential biomarkers and targeted therapies have facilitated the diagnosis and treatment of GC. However, many challenges remain.Expert commentary: To combat GC, sufficient funding is important. More attention should be paid on early diagnosis and the discovery of novel efficient biomarkers and the development of biomarker-based or targeted therapeutics in GC.
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