期刊
DRUG RESEARCH
卷 67, 期 5, 页码 283-288出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/s-0042-123711
关键词
cromolyn sodium; paraquat; proinflammatory cytokines
资金
- Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
The current study aimed to investigate the effects of Cromolyn Sodium (CS) on proinflammatory cytokines in Paraquat (PQ)-induced lung damage in rat. Animals were randomly divided into 5 groups. Group 1 and 2 received nebulized vehicle and CS (8 mg/kg) for 3 consecutive weeks, respectively. Group 3 was treated with single oral dose of PQ (40 mg/ kg). Groups 4 and 5 were PQ groups which received nebulized CS (6 and 8 mg/kg/day, respectively) from 1 week before to 2 weeks after PQ administration. Finally, the animals were scarified and the changes of hydroxyproline (HP) and histology were evaluated in lung tissue. In addition, IL-1 beta, TNF-alpha and IL-8 levels were determined in serum samples. The results showed that lung HP level as well as IL-1 beta, TNF-alpha and IL-8 were significantly lower in the CS treated rats as compared to PQ group. The best response, however, was observed with the 8 mg/kg of CS as confirmed by histology findings. This study suggests that CS may prevent progression of PQ-induced lung damage by decreasing of inflammatory cytokines.
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