期刊
CARBOHYDRATE POLYMERS
卷 163, 期 -, 页码 34-42出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.01.052
关键词
Chitosan; Dialdehyde cellulose; Crosslinking; Cytotoxicity; Protein adsorption
资金
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science and Technology [NRF-2015R1D1A1A01058918]
- Kyung Hee University [KHU-20140321]
Crosslinked chitosan was prepared by Schiff base formation between the aldehyde groups of dialdehyde cellulose (DAC) and the amino groups of chitosan and a subsequent reduction. DAC was obtained through periodate oxidation of cellulose and solubilization in hot water at 100 degrees C for 1 h. Three grades of DAC-crosslinked chitosan were prepared by adding various amounts DAC. The degrees of crosslinking as determined by amino group content were 3.8, 8.3, and 12.1%, respectively. DAC-crosslinked chitosan showed higher stability in the pH 2-9 range and no cytotoxicity was identified over the course of a 21-day long-term stability test. Also, DAC-crosslinked chitosan showed remarkably high bovine serum albumin (BSA) adsorption capacity at pH 5.5 as a result of the increased amino group content, due to the reaction between DAC and chitosan molecular chains occurring at multiple points even though DAC-crosslinked chitosan showed a lower degree of crosslinking. (C) 2017 Elsevier Ltd. All rights reserved.
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