期刊
ANTICANCER RESEARCH
卷 37, 期 5, 页码 2381-2386出版社
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.11576
关键词
Lung cancer; aerosol delivery; gene therapy; importin 7; GPT-SPE
类别
资金
- Research Institute for Veterinary Science, Seoul National University
- BK21 PLUS Program for Creative Veterinary Science Research
Background/Aim: Lung cancer shows the highest estimated deaths in both males and females in the Unites States. Importin 7 is overexpressed in lung adenocarcinoma tissues. In this study, we aimed to demonstrate the anticancer effect of importin 7 down-regulation, especially in lung cancer. Materials and Methods: Glycerol propoxylate triacrylate spermine (GPT-SPE) is a biocompatible carrier used for aerosol gene delivery. Repeated aerosol delivery of GPT-SPE/shImportin 7 complexes was performed to 10-week-old male K-ras(LA1) mice (a murine lung cancer model) twice a week for 4 weeks (8 times) in a nose-only exposure chamber. Results: Aerosol delivery of GPT-SPE/shImportin 7 inhibits lung cancer in K-ras(LA1) mice compared to control and scramble control groups. Moreover, importin 7-down-regulated stable cell-line demonstrates suppression of proliferation through Akt inhibition and apoptosis. Conclusion: Down-regulation of importin 7 significantly suppresses lung cancer in vitro and in vivo.
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