期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 61, 期 5, 页码 -出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02632-16
关键词
colistin resistance; MCR-1.6; IncP plasmid; Salmonella enterica serovar Typhimurium
资金
- Priority Project on Infectious Disease Control and Prevention from the Ministry of Health, China [2015CB554201, 2016YFC1200103]
In this study, we report a novel mcr-1 gene variant, named mcr-1.6, carried by an IncP plasmid in a colistin-resistant Salmonella enterica serovar Typhimurium isolate from a healthy person. Compared with mcr-1, the mcr-1.6 gene contains two single-nucleotide polymorphisms, one of which results in an arginine to histidine variation (Arg536 -> His). The plasmid carrying the mcr-1.6 gene was designated pMCR1.6_P053 and is similar to a recently discovered mcr-1-bearing plasmid found in Klebsiella pneumoniae.
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