期刊
NATURE REVIEWS IMMUNOLOGY
卷 17, 期 5, 页码 281-294出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri.2017.19
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资金
- US Department of Health & Human Services, National Institutes of Health (NIH) [R37AI059714, R01AI128836, R01AI073148]
Immune tolerance hinders the potentially destructive responses of lymphocytes to host tissues. Tolerance is regulated at the stage of immature B cell development (central tolerance) by clonal deletion, involving apoptosis, and by receptor editing, which reprogrammes the specificity of B cells through secondary recombination of antibody genes. Recent mechanistic studies have begun to elucidate how these divergent mechanisms are controlled. Single-cell antibody cloning has revealed defects of B cell central tolerance in human autoimmune diseases and in several human immunodeficiency diseases caused by single gene mutations, which indicates the relevance of B cell tolerance to disease and suggests possible genetic pathways that regulate tolerance.
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