期刊
EXPERIMENTAL AND MOLECULAR MEDICINE
卷 49, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/emm.2017.52
关键词
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资金
- National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea [1420390]
- Basic Science Research Program through the National Research Foundation of Korea (NRF) - Ministry of Education, Science, and Technology [NRF-2014R1A1A4A01005556]
- Dongguk University Research Fund
- KIST Institutional Program [2E26320]
- Korea Health Promotion Institute [1420390-1] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2014R1A1A4A01005556] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The clearance of apoptotic cells is an essential process for tissue homeostasis. To this end, cells undergoing apoptosis must display engulfment signals, such as 'find-me' and 'eat-me' signals. Engulfment signals are recognized by multiple types of phagocytic machinery in phagocytes, leading to prompt clearance of apoptotic cells. In addition, apoptotic cells and phagocytes release tolerogenic signals to reduce immune responses against apoptotic cell-derived self-antigens. Here we discuss recent advances in our knowledge of engulfment signals, the phagocytic machinery and the signal transduction pathways for apoptotic cell engulfment.
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