4.7 Review

Drosophila melanogaster a potential model organism for identification of pharmacological properties of plants/plant-derived components

期刊

BIOMEDICINE & PHARMACOTHERAPY
卷 89, 期 -, 页码 1331-1345

出版社

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2017.03.001

关键词

Drosophila melanogaster; Medicinal plant; Plants/plant-derived components; Pharmacological properties; Development; Behavior

资金

  1. Gujarat Council of Scientific and Technology, New Delhi, India [GUJCOST/MRP/2015-16/2680]
  2. Innovation in Science Pursuit for Inspired Research (INSPIRE) Fellowship, Department of Science and Technology (DST), New Delhi, India [IF140990]

向作者/读者索取更多资源

Plants/plant-derived components have been used from ancient times to treat/cure several human diseases. Plants and their parts possess several chemical components that play the vital role in the improvement of human health and their life expectancy. Allopathic medicines have been playing a key role in the treatment of several diseases. Though allopathic medicines provide fast relief, long time consumption cause serious health concerns such as hyperallergic reactions, liver damage, etc. So, the study of medicinal plants which rarely cause any side effect is very important to mankind. Plants contain many health benefit properties like antioxidant, anti-aging, neuroprotective, anti-genotoxic, antimutagenic and bioinsecticidal activity. Thus, identification of pharmacological properties of plants/plantderived components are of utmost importance to be explored. Several model organisms have been used to identify the pharmacological properties of the different plants or active components therein and Drosophila is one of them. Drosophila melanogaster fruit fly is a well understood, high-throughput model organism being used more than 110 years to study the different biological aspects related to the development and diseases. Most of the developmental and cell signaling pathways and similar to 75% human disease-related genes are conserved between human and Drosophila. Using Drosophila, one can easily analyze the pharmacological properties of plants/plant-derived components by performing several assays available with flies such as survivorship, locomotor, antioxidant, cell death, etc. The current review focuses on the potential of Drosophila melanogaster for the identification of medicinal/pharmacological properties associated with plants/plant-derived components. (C) 2017 Elsevier Masson SAS. All rights reserved.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据