期刊
NATURE REVIEWS CANCER
卷 17, 期 5, 页码 302-317出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc.2017.6
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资金
- US National Cancer Institute [CA169538, CA169416, CA193461-01]
- US Department of Defense [W81XWH-13-1-0427, W81XWH-13-1-0249, W81XWH-14-1-0199, W81XWH-15-1-0201]
- Hartwell Foundation
- Manning Foundation
- Sohn Foundation
- STARR Consortium
- POETIC Consortium
- Paduano Foundation
- Alex's Lemonade Stand Foundation
- Champalimaud Foundation
- 5th District AHEPA Cancer Research Foundation
- Daedalus Fund (Weill Cornell Medicine)
- MINECO [SAF2014-54541-R]
- ATRES-MEDIA - AXA
- Asociacion Espanola Contra el Cancer
- WHRI Academy
- Worldwide Cancer Research
- Susan Komen Foundation For the Cure Fellowship
- Novo Nordisk Foundation
- Peter Oppenheimer Fellowship - American Portuguese Biomedical Research Fund
- National Breast Cancer Coalition's Artemis Project
- Pink Gene Foundation
- Wellcome Trust [107477/Z/15/Z] Funding Source: Wellcome Trust
- Academy of Medical Sciences (AMS) [AMS-SGCL10-Psaila] Funding Source: researchfish
- European Hematology Association [TRTH100] Funding Source: researchfish
- National Institute for Health Research [CL-2012-21-004] Funding Source: researchfish
- Novo Nordisk Fonden [NNF12OC1015992] Funding Source: researchfish
- Wellcome Trust [107477/Z/15/Z] Funding Source: researchfish
It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.
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