期刊
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
卷 1860, 期 5, 页码 636-644出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbagrm.2016.10.012
关键词
NUCLEAR FACTORY (NF-Y); Plant development; Abiotic stress responses; Primary metabolism; Transcription factor
资金
- National Science Foundation [IOS 1149822]
- University of Oklahoma Research Council
- University of Oklahoma Office of the Dean for Arts and Sciences
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1149822] Funding Source: National Science Foundation
NUCLEAR FACTOR-Y (NF-Y) is a heterotrimeric transcription factor (TF) consisting of evolutionarily distinct NF-YA, NF-YB and NF-YC subunits. The functional NF-Y heterotrimer binds to CCAAT elements in eukaryotic gene promoters and influences their expression. The genome of the model organism Arabidopsis thaliana encodes 10 distinct NF-YA, NF-YB, and NF-YC proteins, allowing for enormous combinatorial and functional diversity. Two decades of research have elucidated the importance of NF-Ys in plant growth, development and stress responses; however, the molecular mechanisms of action remain largely unexplored. Intriguingly, recent evidence suggests that NF-Ys are frequently associated with other groups of TFs, expanding the potential NF-Y combinatorial complexity. Further, information regarding the regulation of individual NF-Y subunits at the transcriptional and post-transcriptional level is beginning to emerge. In this review, we will identify developing trends within the NF-Y field and discuss recent progress towards a better understanding of NF-Y function, molecular action, and regulation in the context of Arabidopsis. This article is part of a Special Issue entitled: Nuclear Factor Yin Development and Disease, edited by Prof. Roberto Mantovani. Published by Elsevier B.V.
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