期刊
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
卷 77, 期 5, 页码 -出版社
WILEY
DOI: 10.1111/aji.12651
关键词
aging; mitochondria; ovary; reproduction
资金
- National Institute of Health [R01HD059909]
Mitochondria are double-membrane-bound organelles that are responsible for the generation of most of the cell's energy. Mitochondrial dysfunction has been implicated in cellular senescence in general and ovarian aging in particular. Recent studies exploited this association by studying mitochondrial DNA (mtDNA) copy number as a potential biomarker of embryo viability and the use of mitochondrial nutrients and autologous mitochondrial transfer as a potential treatment for poor ovarian function and response.
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